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Poison Ivy, AKA Pamela Isley, first appeared in Batman #181. Her blood is quite literally toxic, but her pheromone scent is absolutely intoxicating.
It takes true sex appeal to have a name reminiscent of uncomfortable itching but to still have men falling all over you. Some villains strike at Batman's loved ones, some at his partner, but Poison Ivy goes straight for the Bat. Coy, sexy and very deadly, we can see why so many men fall under her spell.
All of Batman's foes wield a certain advantage over the Dark Knight that makes them a formidable opponent. For the Scarecrow, that advantage is fear. For Two-Face, it's the feelings of guilt he inspiress. Pamela Isley lands on this list because she employs two deadly weapons that are as old and primitive as time itself: Sex and mind-control (or are they the same thing? We can never be sure).
Ivy adds some much needed estrogen to Batman's rogues' gallery, proving that terrorizing Batman and Gotham City isn't a job for men alone. With her hypnotic powers and her ability to control plant life, she's also one of Bats' few super-powered foes. Whether she's turning Gotham's version of Central Park into her own twisted jungle playground, tearing up the town with Harley Quinn, or terrorizing Gotham's elite industrialists or brain-washing Superman to kill Batman, Ivy always proves a worthy adversary. The point is that a relatable, sympathetic person exists deep within the Poison Ivy character, and that's the most essential ingredient for any great antagonist. Plus, she's deadly, ruthless and sexy as all hell.