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Death. Eternity. The origins of the universe. These concepts and beings are fundamental to the existence of the Marvel Universe. Equal to these, however, is the next member of our Top Villains list - Galactus. Despite his rather garish appearance, the being formerly known as Galan lived before the birth of the modern cosmos, and is as fundamentally important to it as entities responsible for the creation and elimination of life. Galactus, in his destruction of planets, brings balance to the universe, just as life is given and taken every day on Earth.
It's this larger than life presence which makes Galactus one of the more important villains ever created, but it's his ties to Earth and its heroes that make him one of the greats. Through the creation of his heralds, destruction of the Skrull Empire and attempts to devour the Earth, this being is one of the greatest threats ever known to our beloved heroes. Most other villains pale in comparison.
Lastly, though it seems like something small, we can't overlook it. Galactus is one of the few villains on our list to really defy the definition of an evil-doer. He's compelled to destroy worlds because of one simple fact - he's hungry. Can't blame a guy for wanting a little snack… can you?