For a more detailed breakdown of the requirements of each trophy, consult the existing trophy guide. While it is a good guide, the walkthrough here strives to be more efficient in the number of playthroughs you have to do, as that guide advises 6 playthroughs, but it can be reduced down to 5. Every other trophy can be crammed into four playthroughs, but because there are 5 major endings, a 5th full playthrough must be done just to unlock  Thank You. That trophy keeps a running total of the major endings that have been seen, which is why save scumming near the end of the game does not reduce the amount of required playthroughs. It is still recommended to periodically stop to back up the save file in case a wrong selection is made on a choice, as it typically auto-saves after every important choice. The game can be paused at any time with the button. Each playthrough can vary in length from 1 hour and 40 minutes to 2 hours depending on the choices required, some routes take longer to complete than others.There are minor spoilers below uncovered in the list of the 5 major endings. In the sections beyond are detailed walkthrough instructions. A few spoiler tags have been placed to minimize major spoilers, but that's the nature of a choice-by-choice walkthrough. Facts learned in prior playthroughs will not be marked as spoilers in subsequent playthroughs, so do not read too far ahead.One thing to remember is that progress toward trophies is saved over multiple playthroughs, but the trophies unlocked on that run do not pop until the credits roll. For example, the conditions for  Magic! are fulfilled almost immediately, but it won't unlock until the end of Playthrough #1.

Regarding "Major Endings"

There was confusion in the trophy guide about what constitutes a "major ending" for  Thank You (the description says, "See all major endings."). The guide suspected that since there were trophies for 5 endings, it, at minimum, required doing those 5 separate playthroughs and perhaps the 6th, which is a variant of another. After testing the original 4-playthrough guide and then experimenting further on an alternate PSN account, it has been determined there are 5 major endings, but they aren't the ones mentioned in the trophy guide. 3 of the major endings unlock trophies; the other 2 endings required for  Thank You don't technically unlock trophies, but those ending choices lead to 1 of 2 epilogues that do unlock trophies based on choices made a little earlier in the story.The 5 Major Endings are:

1. An Erica no-killing run in which you stay with Lucien by choice.
2. An Erica killing some run in which you stay with Lucien under duress.
3. A run in which you:
   •  kill Lucien, breathe in the lamp, and accept the Mask.
4. A run in which you:
   • kill Lucien, breathe in the lamp, and reject the Mask, accidentally burning down Delphi House.
5. A run in which you:
   • kill Lucien, DO NOT breathe in the lamp, purposefully burning down Delphi house.
   • Major endings #4 & #5 end the same, but you get there by slightly different means, which is why both are required.

 Into the Moonlight or  Not Alone are both compatible with major endings #4 or #5, which is why a 6th playthrough is not needed.

The goal of this playthrough is to hinder Sergeant Blake's investigation as much as possible by giving unhelpful responses while also ensuring nobody dies at Erica's hands.

PROLOGUE - Erica as a child

IMPORTANT INSTRUCTIONS	TROPHY PROGRESS
Find your favorite card again from the face-down cards Picture locations: Nurse (left), Pregnant (center), Wedding (right)	Magic! (1/1)
Make whatever choices you want as adult Erica lounges in her apartment. The next morning, she will receive a package.

ACT I-A - Erica talks to the police and goes to stay at Delphi House

IMPORTANT INSTRUCTIONS	TROPHY PROGRESS
Be negative/unhelpful to Blake in all responses in this playthrough  Rip out the journal page  Question  Relevance	Progress toward Failure to Comply
At the Lobby of Delphi House: Pound the bell on the counter, then look at the painting Select to answer the phone Select left to go to the office	Service! (1/1)
Inside the back office Interact with the desk to open it Select the typewriter Read the front of the note and then flip it to read the back	Paperwork (1/10)
Interact with the top-left drawer Click the bottom right of the notepad, then scratch over it	Paperwork (2/10) Enigma (1/2)
Interact with the top right drawer and grab the key Turn off the radio all the way to the left	S Ranking (1/2)
Open the cage door with the key  Open the file cabinet Read Alodie Carter's file, and be ready for a QTE after exiting	Paperwork (3/10)
QTE - Quickly interact with the window on the right	S Ranking (2/2)
Look to the right in the clearing to see a Fox	Foxy (1/4)
Don't tell Blake about the call or the masked girls; say "Sorry"

Act I-B - Erica's first day at Delphi House

IMPORTANT INSTRUCTIONS	TROPHY PROGRESS
Wake up and go down the stairs to see Kirstie cleaning the carpet
Click the middle hallway to walk over the carpet to annoy her	Fall Out Girl (1/3)
When Kirstie arrives in the Music Room, tell her to "Get Help"	Keeping the Peace (1/1)
After the small talk with Lucien, tell Blake:  Doubt Hopeless Refuse the therapy Click on the Fox by the fountain	We Need to Talk (1/3) Foxy (2/4)
After a talk with Lucien, choose "Check on Tobi" and answer: Defy Comfort, to annoy Tobi	We Need to Talk (2/3) (NOT hanging out with Hannah) Fall Out Girl (2/3)
Annoying Tobi sends you to lunch with Kirstie: Complete her hang-out by doing what she says Look under the pillow	Proud Father (1/2) Kirstie's BFF (1/1)
Back in your room with Hannah: Challenge Insist Decline, to reject the perfume diffuser Bin it to annoy Hannah	Fall Out Girl (3/3)
Wake up to see a petal in your toes, then open a gift once inside	Botanist (1/6)
Discuss the gifted doll with Blake and Lucien, and leave with Blake

ACT II - Return to Erica's apartment, second day at Delphi House, and visit the chief inspector

IMPORTANT INSTRUCTIONS	TROPHY PROGRESS
Disobey by following Blake into the apartment next door  Click lamp  Click fridge	Botanist (2/6)
Ignore Blake's order to leave by clicking on the left door to see Steinbeck's body	I See Dead People (1/8)
Back at Delphi House with Kirstie: Sign the card for Hannah.   She will then show you a secret entrance in her closet	Calligraphy (1/1) Backstage Pass (1/5)
Peek around the corner at Tobi in Hannah's room	Voyeur (1/10)
At the chief inspector's house, receive a note, then insist on leaving	We Need to Talk (3/3)
In the bathroom, directly click on the door on the right; do NOT click on the window since that will cause you to miss something	Paperwork (4/10) Proud Father (2/2) I See Dead People (2/8)
Under the photo in the drawer: Click the notebook inscribed with "AJ" before clicking the medallion	Paperwork (5/10) Enigma (2/2)

ACT III - Final night at Delphi House

The last act begins with Erica returning to Delphi House from the inspector's residence and walking up the stairs with Blake:

IMPORTANT INSTRUCTIONS	TROPHY PROGRESS
Dismiss Blake Berate That's not true Lie to Blake about the farmhouse
Lean out of the room to watch a scene with Blake and Ballard Reassure Kirstie Enter the cabinet to go underground	Voyeur (2/10)
Enter the Red Room and interact with the gurney at the front of the room to see Hannah	I See Dead People (3/8)
Interact with the center Blue Room to spy on Ballard	Voyeur (3/10)
You'll automatically move into the next room: Click on the desk with the beakers to spy on Ballard again	Voyeur (4/10)
Click the left passage to Exit the underground Repeatedly Reject Mia Greene to see a petal	Botanist (3/6)
Back at Delphi House: Accuse Blake, then see him get shot by Greene	Failure to Comply (1/1) I See Dead People (4/8)
Let Ballard escape by not shooting her Save Tobi with an Epinephrine shot from the fridge (brown liquid in the lower right corner)	Hero (1/1)
Do not shoot Lucien, then accept his help	Happy Family (1/1) Thank You (1/5) Innocent (1/1)

This unlocks:  Service!,  S Ranking,  Proud Father,  Enigma,  We Need to Talk,  Keeping the Peace,  Calligraphy,  Magic!,  Kirstie's BFF,  Fall Out Girl,  Hero,  Happy Family,  Innocent, and  Failure to Comply.

The goal is to be more positive and cooperative with Sergeant Blake for most of the story, then betraying his trust nearer the end, then having the playthrough end by opting to remain with Lucien at Delphi House under duress.

ACT I - Erica talks to the police and then spends a day at Delphi House

IMPORTANT INSTRUCTIONS	TROPHY PROGRESS
Be cooperative/helpful to Blake in all responses in this playthrough: Hand over the entire journal Cooperate
At the lobby of Delphi House: Answer the phone Click right to immediately go outside Tell Blake about the call
In the meeting with Lucien, tell Blake:  Help Helpful Accept therapy to see petals on the slides	Botanist (4/6)
After therapy, go to Make Perfume with Hannah  Select Get Matches
Open the left drawer Select the article on the left Leave early	Paperwork (6/10)
Back in your room, tell Lucien: "I think you should go" Turn on the perfume diffuser	Personal Space (1/1)

ACT II - Return to Erica's apartment, second day at Delphi House, and visit the chief inspector

IMPORTANT INSTRUCTIONS	TROPHY PROGRESS
Disobey by following Blake into the apartment next door:  Click the lamp Click the picture Warn Blake	Voyeur (5/10)
Click the picture again Answer the phone and stay on the call	Voyeur (6/10)
At the chief inspector's house: Identify the photo Accept staying Click on the window in the bathroom to see a Fox	Foxy (3/4)

ACT III - Final night at Delphi House

IMPORTANT INSTRUCTIONS	TROPHY PROGRESS
After returning to Delphi House from the inspector's residence: Worry Berate Going Crazy Kiss Blake
Lie to Blake about the farmhouse to go underground	Backstage Pass (2/5)
Directly click the left door In the next room, click the left door to see a scene Click the same left door again to leave the underground	Voyeur (7/10)
Accept Mia Greene's offer and try to enter the greenhouse	Backstage Pass (3/5)
Ask Greene to Show Erica how to use the knife Have Erica kill the guard Once inside, peek to the left to watch Dr. Ballard	I See Dead People (5/8) Voyeur (8/10)
After you turn off the lights, Blake attacks. Push him Grab the knife Stab him	Backstabber (1/1)
Select the gun in the middle of the options to kill Ballard Inject Lidocaine (the clear liquid to the lower left) Wipe Tobi's cheek	I See Dead People (6/8) & (7/8) Farewell (1/1)
Do not shoot Lucien; accept his help Get tranquilized for killing	Prisoner (1/1) Thank You (2/5)

This unlocks:  Farewell,  Personal Space,  Backstabber, and  Prisoner.

ACT I - Erica talks to the police and then spends a day at Delphi House

IMPORTANT INSTRUCTIONS	TROPHY PROGRESS
At the lobby of Delphi House:  Follow the 3 masked girls down the hall Peek into the office on the right	Voyeur (9/10)
In the meeting with Lucien:  Reject therapy Afterward, click on Hannah to the right of the fountain
Select Check on Tobi, and answer: Defuse  Stay Cool Question Drink and Answer (do not leave) to see a drawing and a secret passage	Tobi's BFF (1/1) Paperwork (7/10) Backstage Pass (4/5)

ACT II - Return to Erica's apartment, second day at Delphi House, and visit the chief inspector

IMPORTANT INSTRUCTIONS	TROPHY PROGRESS
Disobey by following Blake into the apartment next door, then click the left room to inspect a corpse: Click the chest Breast pocket for a scrap of paper Open the mouth for petals	Paperwork (8/10) Botanist (5/6)
Follow Tobi from the piano to Hannah's room and spy on Ballard	Voyeur (10/10)
Find the jewelry box in the cabinet next to Hannah's bed  Open the side drawer of the box	Botanist (6/6)

ACT III - Final Night at Delphi House

IMPORTANT INSTRUCTIONS	TROPHY PROGRESS
After returning to Delphi House from the inspector's residence:  Tell Blake the truth to go to the farmhouse together Click the car's glovebox to read Blake's notebook	Paperwork (9/10)
Accept or Reject Mia Greene Kill or save Ballard Kill or save Tobi
Select the gun in the middle of the options to kill Lucien (or wait for the prompt)  Unlock the door with his medallion	I See Dead People (8/8) Backstage Pass (5/5)
Light the lamp Breathe in the lamp Accept the Mask	The Butterfly (1/1) Thank You (3/5)

This unlocks:  Tobi's BFF,  The Butterfly,  I See Dead People,  Voyeur,  Botanist, and  Backstage Pass.

The major goals of this playthrough are to ensure that everybody dies, see the Fox at every opportunity, and find all the hidden documents, while also making perfume with Hannah, slapping Tobi, and finding the Delphic Epsilon slide in the lab along the way.

ACT I - Erica talks to the police and then spends a day at Delphi House

IMPORTANT INSTRUCTIONS	TROPHY PROGRESS
Make whatever choices until the meeting with Lucien:  Reject therapy
Select to Make Perfume with Hannah: Select Get Matches Read the file on top of the desk Apologize and finish the hangout	Paperwork (10/10) Hannah's BFF (1/1)

ACT II - Return to Erica's apartment, second day at Delphi House, and visit the chief inspector

IMPORTANT INSTRUCTIONS	TROPHY PROGRESS
Obey Blake and stay in your apartment to see the last Fox	Foxy (4/4)
In Hannah's room: Refuse to give Tobi the box Slap her	Impulsive (1/1)

ACT III - Final night at Delphi House

IMPORTANT INSTRUCTIONS	TROPHY PROGRESS
After returning to Delphi House from the inspector's residence: Lie to Blake to go underground
Enter the Red Room: Touch the TV screen Keep clicking Next (center button).  Exit the underground by clicking the door to the left	Subliminal (1/1)
Accept Mia Greene Kill the guard Stab Blake Shoot Ballard by selecting the gun
Kill Tobi via improper injection (clear liquid), then shoot Lucien
Light the lamp Breathe in the lamp Reject the Mask	Into the Moonlight (1/1) No Survivors (1/1) Thank you (4/5)

This unlocks:  Impulsive,  Subliminal,  Hannah's BFF,  Into the Moonlight,  No Survivors,  Foxy, and  Paperwork.

Finally, you will be getting the final ending, in which Delphi House is burned down, to finish off all the endings.

IMPORTANT INSTRUCTIONS	TROPHY PROGRESS
You can literally pick any responses you want until near the end of the playthrough. Silence (letting the timer run without picking a response) is a valid option most of the time and can elicit some unique responses. For the fastest route to the next choice, look to the right.	The fastest route: Make Perfume with Hannah Tell Blake the truth about the farmhouse Accept Mia Greene

ACT III - Final night at Delphi House (after your encounter with Ballard in the underground)

IMPORTANT INSTRUCTIONS	TROPHY PROGRESS
Save Tobi with an Epinephrine shot (brown liquid on lower right) Tell them to leave Delphi House Shoot Lucien
Light the lamp, but DO NOT breathe it in Throw the lamp to burn down Delphi House	Not Alone (1/1) Thank you (5/5)

This unlocks:  Not Alone,  Thank You, and  That's a Wrap.