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Withdrawn appetite suppressant drug
Amfecloral Other names alpha-methyl-N -(2,2,2-trichloroethylidene)phenethylamine;N -(2,2,2-trichloroethylidene)amphetamine ATC code Legal status
2,2,2-trichloro-N -(1-phenylpropan-2-yl)ethanimine
CAS Number PubChem CID ChemSpider UNII KEGG ChEMBL CompTox Dashboard (EPA ) Formula C 11 H 12 Cl 3 N Molar mass 264.57 g·mol−1 3D model (JSmol )
ClC(Cl)(Cl)/C=N/C(Cc1ccccc1)C
InChI=1S/C11H12Cl3N/c1-9(15-8-11(12,13)14)7-10-5-3-2-4-6-10/h2-6,8-9H,7H2,1H3/b15-8+
Y Key:VBZDETYCYXPOAK-OVCLIPMQSA-N
Y
N Y (what is this?) (verify)
Amfecloral (INN ), also known as amphecloral (USAN ), is a stimulant drug of the phenethylamine and amphetamine chemical classes that was used as an appetite suppressant under the trade name Acutran , but is now no longer marketed.[1] It was classified as an anorectic drug with little to no stimulant activity in a 1970 review.[2] The British Pharmacopoeia Commission approved the name in 1970.[3] The raw ingredients used in manufacturing it were d-amphetamine and chloral hydrate .[4]
Pharmacology [ edit ]
Amfecloral is metabolised to both d-(S)- and l-(R)-amphetamine and, most likely, also to chloral hydrate.[5] Amphetamine is a psychostimulant , whereas chloral hydrate is a sedative/hypnotic drug.
The extent of metabolism and in-vivo contribution of a chloral hydrate metabolism to its purported "little to no stimulant activity" is unknown.
See also [ edit ]
References [ edit ]
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