Don't spend too much time early on doing all the side areas... Advance the main plot, too. I finished all the sides areas before moving to the main story missions and now I've got a ton of hours long war table missions that have popped up and very few ways to kill time outside of doing story missions. I'm going to end up picking up a few missions and then playing a new character while I wait for them to finish, especially considering some of these missions are part of companions stories.
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