Wasamon Nutakul, PhD

I'm thrilled to share a new publication led by my teammate, Shaminie Athinarayanan, PhD, which thoroughly reviews the impact of ketogenic diets on kidney health. This paper tackles prevalent misconceptions about ketogenic diets, such as concerns over high protein content, that have hindered their adoption in populations that could benefit. Check out this important review [https://lnkd.in/g6BA_yqH], which we hope will inspire further research into the potential benefits of ketogenic diets for individuals with kidney disease.

39

1 Comment

How does seasonality impact the bio-available nutrition in fruits and vegetables? Nutrition scientist and IFM educator Deanna Minich, MS, PhD, FACN, CNS, IFMCP recently joined us on "Pathways to Well-Being" to discuss the relationship between seasonal variability, nutrition, health, and the human body’s internal clock. In the following segment, Dr. Minich gives a preview of some of the research she will explore in her main stage presentation at our upcoming Annual International Conference (AIC). Watch or listen to the rest of this colorful episode here: https://hubs.la/Q02wq1cr0

41

2 Comments

Great work on targeted protein degradation (TPD) from Yunrui QIU and collaborators at University of Wisconsin - Madison. Yunrui did an internship with us at Roivant Sciences a few years ago and continued to work on heterobifunctional degraders, culminating in this excellent work. This work presents a physics-based computational protocol to systematically predict non-canonical and metastable PPI interfaces between an E3 ligase and a given POI, aiding in the design of linkers to stabilize the PROTAC ternary complex and enhance degradation. The overall process is depicted in Figure 1 (below), which includes non-Markovian dynamic modeling from approximately 1.5 milliseconds of molecular dynamics (MD) simulations of linker-less encounter complexes, to systematically explore the energetically favorable PPIs between the KRAS and the VHL E3 ligase. This approach revealed six metastable states each containing a different PPI interface, with three of these metastable states containing promising PPIs for linker design. One of the top PPIs prospective predictions closely matches a recent co-crystal PPI interface structure induced by an experimentally designed PROTAC with potent degradation efficacy. You can read the full paper on #bioRxiv: https://lnkd.in/eUzKdyHY Recognition to Rafal Wiewiora, Jesus Izaguirre, and Huafeng Xu for working with Yunrui in NYC and also Weiping Tang and Xuhui Huang for overseeing the project. #tpd #protac #drugdesign #computationalchemistry #moleculardynamics

161

3 Comments

Check out this review article titled “Addressing vitamin D deficiency through nutritional strategies” in our journal Bioactive Compounds in Health and Disease: https://lnkd.in/gXHD9Zyy. This article was written by Tori Trachtenberg and Danik Martirosyan. The review examines the global health impacts of vitamin D deficiency, which affects cardiovascular, immune, and brain health. It discusses strategies to combat deficiency, including dietary changes, food fortification, and supplementation. A key biomarker for Vitamin D deficiency is serum 25(OH)D levels below 20 ng/mL. Vitamin D3 is preferred for supplementation due to its higher bioavailability, but careful dosage is necessary to avoid toxicity. Fortifying foods with vitamin D is a promising method to address deficiency and improve health. The Functional Food Center provides a regulatory framework for developing fortified products, highlighting the need for compliance and clinical validation. Continued research is needed to confirm the effectiveness of these functional foods. Follow our LinkedIn page at https://lnkd.in/g-8YYvHB Email: editor@ffhdj.com Sincerely, Functional Food Center

7

Look what I found today (thanks Mingyung Leer and Seongwon Seo; sorry I'm so slow to get to it): https://lnkd.in/g4eJnzU2. I love science! Wearable tech for livestock, like ear tags and collars, can track everything from how much a cow eats to how often they move. This data helps farmers catch health issues early, making cows happier and farms more efficient. Easy to see how it could support antibiotic stewardship programs on farms and promote the sustainable use of antimicrobials too. Also, so much fun for marketing - for example: Honest Eggs Co.'s FitChix (LOL!!!!!) https://lnkd.in/gJHwcCFy For more details, check out the full article that got me musing (https://lnkd.in/g4eJnzU2).

1

1 Comment

Please join us for this interactive session and how the newest of the Global Institute for Food Security technology platforms can accelerate innovations for the agriculture and agri-food industry.

3

Email from Foods journal this morning. The article written by Nutritional Insight on Food Based Dietary Guidelines - Time to Encompasd Mycoprotein? …is now one of their most highly read/viewed/downloaded articles. Great to see that so many people are interested in reading about this!! https://lnkd.in/efdaHyjZ #nutritionalinsight. #scientificresearch. #scientificwriting

31

2 Comments

Great article! Gives me a lot to think about on the subject of lab grown foods of the future and the environmental and human costs of how we make food in the present. I think I'll wait till after #SynBioBeta2024 to form an opinion. What do you think?

11

1 Comment

I encourage you to delve into the full article to grasp the depth of this groundbreaking research and its implications for the future of agriculture. Together, let's nurture a greener, more sustainable world through science and stewardship. 🌍💚 #OrganicFarming #PlantGenetics #Sustainability #AgriculturalInnovation

2

Some great resources from NutritionFacts.org: https://lnkd.in/giJXkXPc. I especially like the infographic on plant-based meat alternatives. #NutritionFacts.org #alternativeprotein #infographics

1

1 Comment

𝗧𝗵𝗲 𝗽𝗼𝘁𝗲𝗻𝘁𝗶𝗮𝗹 𝗼𝗳 𝗱𝗶𝗲𝘁𝗮𝗿𝘆 𝗴𝗹𝘂𝘁𝗮𝗺𝗶𝗻𝗲 𝗮𝗻𝗱 𝗴𝗹𝘂𝘁𝗮𝗺𝗮𝘁𝗲 𝗶𝗻 𝗿𝗲𝗱𝘂𝗰𝗲𝗱 𝗰𝗿𝘂𝗱𝗲 𝗽𝗿𝗼𝘁𝗲𝗶𝗻 𝗯𝗿𝗼𝗶𝗹𝗲𝗿 𝗱𝗶𝗲𝘁𝘀 Shemil Macelline, Peter Chrystal, MEDHI TOGYANI, Peter Selle and Sonia Liu review the potential of dietary glutamine (Gln) and glutamate (Glu) fortification in reduced-crude protein (CP) broiler diets and suggest it may be more rewarding to fortify reduced-CP broiler diets with dietary Gln than Glu as Glu may be more extensively catabolised in enterocytes. Click here to read the article: https://lnkd.in/gF8pADMY #broilerchickens #glutamate #glutamine #reduceproteindiets

3

Today I had the distinct honor of moderating an #IAFNS Scientific Symposium panel on AI in nutrition science and food safety. It was a pleasure to interact with some of the most thoughtful experts in the field: - Dr. Benoit Lamarche University of Laval in Quebec, Canada, - Dr. Martin Wiedmann Cornell University, - Dr. Ernest Kwegyir-Afful US FDA, - Dr. Alexandra Johnston, Ph.D. Georgetown University.  Besides taking the opportunity to briefly share how AI accelerates Bioscience at IFF product development, my interaction with the speakers resulted in a number of takeaways: 1. Garbage in, garbage out! When input data is inadequate, do not expect much more from AI than you could obtain with traditional statistics. Voluntary survey data of low quality and/or variable environmental effects complicate successful application of AI, even for personalized nutrition. 2. Don’t hammer a screw! Just like #Biotech, AI is a tool in a large toolbox and not necessarily always the most appropriate one. Data sharing will be crucial for reliable application of AI in food safety. But who will readily share such data? 3. Terminology matters! Chemicals added to food and food ingredients aren’t seen as the same by the general public. 4. The AI toolbox is taking more and more humanized forms. Besides Food Babe, your neighbor and/or your mom (all of whom are relatively easily ignored if you put your mind to it, at least on the topics of nutrition and food safety) you now have to contend with another information source - this one seems objective and 'correct' but it's humanized form blurs the boundaries between what’s observed and what's predicted. This may be one of the greatest pitfalls for broad consumer use of AI. #artificialintelligence #nutrition #foodsafety #socialsciences #language IAFNS - Advancing Food and Nutrition Sciences Wendelyn Jones

58

3 Comments

Your food should be as varied as your Spotify playlists. Biomarkers of Food Intake (BFI) make sure it's legit. In this interesting publication, they have analyzed BFIs with three key criteria: plausibility, robustness, and reliability of the Biomarkers. Validation involves: 1. Discovery studies: Like swiping right on potential BFIs through metabolomics. 2. Confirmation studies: Double-checking those matches. 3. Prediction studies: Making sure it works for everyone, not just your squad. With more validation studies, in a near future BFIs will help understand the way we metabolize foods and correlate with other health biomarkers as well.

13

Exploring natural genetic diversity in a bread wheat multi-founder population: Dual imaging of photosynthesis and stomatal kinetics https://lnkd.in/g-9Cr8QY

7

Delighted to share that my latest review on Monkeypox, crafted under the expert guidance of Dr. Balram Omar , has just been published! 📝🔬 Explore the fascinating journey of Monkeypox from pandemic to endemic status in this comprehensive review. Curious to learn more? Dive into the details here: https://lnkd.in/gSG-3msc Let's continue pushing the boundaries of knowledge together! 🚀 #Monkeypox #Research #Healthcare #Publication #Science

31

4 Comments