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In a world where outbreaks of dangerous creatures known as "Kaii" have become commonplace, society has had to adjust. Kaii incidents are now dealt with by companies that deploy Magical Girls— working women equipped with hi-tech brooms to fly around town and spells coming from state-of-the-art software that can be cast by wands. As the number of Kaii incidents have surged, so have the number of magical girl corporations, and the position of "magical girl" is now a highly sought after career.

Kana Sakuragi is a recent college graduate with excellent memory that has been having a hard time job-hunting. When she's caught in the middle of a Kaii incident during an interview, she meets Hitomi Koshigaya, a hot-blooded Magical Girl sent there to neutralize the Kaii. Seeing Kana's immense skill in dealing with the software involved in being a Magical Girl, Kana is immediately recruited to join her in a Magical Girl start-up, Magilumiere. Despite the eccentricity of the company, like the nervous engineer and the cross-dressing Magical Girl fanboy company president, Kana finds herself both intrigued and out of options, prompting her to join the company as a newbie Magical Girl.