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Novel biologically active pyridine derivatives: Synthesis, structure characterization, in vitro antimicrobial evaluation and structure-activity relationship
The rate of microbial resistance has continued to rise significantly as the availability of new antibiotics has declined. A new series of pyridine...
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Prediction of protein structure and AI
AlphaFold, an artificial intelligence (AI)-based tool for predicting the 3D structure of proteins, is now widely recognized for its high accuracy and...
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HDL Structure
HDL has various protein components, including enzymes, complement components, apolipoproteins, protease inhibitors, etc. In addition to proteins,...
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Virus Mechanics: A Structure-Based Biological Perspective
A virus particle possesses a certain degree of stiffness, brittleness, strength against disruption by mechanical force, and resistance to material...
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The Genetic Structure of the Russian Horse Breed
AbstractA total of 166 horses of the Russian Riding breed were studied using 17 microsatellite loci recommended by ISAG. Microsatellite polymorphism...
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Classification and Gene Structure of Aquaporins
Aquaporins (AQPs) are a family of membrane water channels that basically function as regulators of intracellular and intercellular water flow. To...
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Structure, function and drug discovery of GPCR signaling
G protein-coupled receptors (GPCRs) are versatile and vital proteins involved in a wide array of physiological processes and responses, such as...
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Structure-guided discovery of highly efficient cytidine deaminases with sequence-context independence
The applicability of cytosine base editors is hindered by their dependence on sequence context and by off-target effects. Here, by using AlphaFold2...
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KDM4 Demethylases: Structure, Function, and Inhibitors
KDM4 histone demethylases mainly catalyze the removal of methyl marks from H3K9 and H3K36 to epigenetically regulate chromatin structure and gene...
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Intelligent ankle–foot prosthesis based on human structure and motion bionics
The ankle–foot prosthesis aims to compensate for the missing motor functions by fitting the motion characteristics of the human ankle, which...
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Chromatin structure and dynamics: one nucleosome at a time
Eukaryotic genomes store information on many levels, including their linear DNA sequence, the posttranslational modifications of its constituents...
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Monoclonal Antibodies: From Structure to Therapeutic Application
The exciting field of therapeutic monoclonal antibodies (mAbs) had its origins when Köhler and Milstein presented their murine hybridoma technology...
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Electronic Structure of Organic Molecules
In this chapter, the electronic structure of organic molecules is explained starting from the simple Lewis approach about electron pairs, to the...
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Structure of ZP
The zona pellucida (ZP) or egg coat is an architecture that surrounds animal oocytes from fish to mammals. ZP is composed of three to four...
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Structure of monkeypox virus poxin: implications for drug design
Monkeypox, or mpox, is a disease that has recently resurfaced and spread across the globe. Despite the availability of an FDA-approved vaccine...
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Deciphering the genetic structure of the Quebec founder population using genealogies
Using genealogy to study the demographic history of a population makes it possible to overcome the models and assumptions often used in population...
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Causal relationship between multiple sclerosis and cortical structure: a Mendelian randomization study
BackgroundObservational studies have suggested an association between multiple sclerosis (MS) and cortical structure, but the results have been...
