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Dynamics of Collagen Synthesis after Liver Trauma in in vivo Experiments
The results of a comparative study of the dynamics of serum hydroxyproline levels in laboratory animals after liver injury during laparoscopy and the...
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lncRNA CDKN2B-AS1 regulates collagen expression
The long noncoding RNA CDKN2B-AS1 harbors a major coronary artery disease risk haplotype, which is also associated with progressive forms of the oral...
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Schwann cell derived pleiotrophin stimulates fibroblast for proliferation and excessive collagen deposition in plexiform neurofibroma
Neurofibromatosis type 1 associated plexiform neurofibroma (pNF) is characterized by abundant fibroblasts and dense collagen, yet the intricate...
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Long-Term Course of Circulating Elastin, Collagen Type I, and Collagen Type III in Patients with Spontaneous Cervical Artery Dissection: a Prospective Multicenter Study
An impaired integrity of vascular elements and the extracellular matrix (ECM) has been discussed to play a critical role in the pathophysiology of...
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Intradermally delivered mRNA-encapsulating extracellular vesicles for collagen-replacement therapy
The success of messenger RNA therapeutics largely depends on the availability of delivery systems that enable the safe, effective and stable...
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Environmental tobacco smoke exposure exaggerates bleomycin-induced collagen overexpression during pulmonary fibrogenesis
Environmental tobacco smoke (ETS) is known to cause lung inflammatory and injurious responses. Smoke exposure is associated with the pathobiology...
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Understanding the matrix: collagen modifications in tumors and their implications for immunotherapy
Tumors are highly complex and heterogenous ecosystems where malignant cells interact with healthy cells and the surrounding extracellular matrix...
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HTRA1-driven detachment of type I collagen from endoplasmic reticulum contributes to myocardial fibrosis in dilated cardiomyopathy
BackgroundThe aberrant secretion and excessive deposition of type I collagen (Col1) are important factors in the pathogenesis of myocardial fibrosis...
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IRE1α protects against osteoarthritis by regulating progranulin-dependent XBP1 splicing and collagen homeostasis
Osteoarthritis (OA) is a full-joint, multifactorial, degenerative and inflammatory disease that seriously affects the quality of life of patients due...
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Multiscale Label-Free Imaging of Fibrillar Collagen in the Tumor Microenvironment
With recent advances in cancer therapeutics, there is a great need for improved imaging methods for characterizing cancer onset and progression in a...
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Collagen in the central nervous system: contributions to neurodegeneration and promise as a therapeutic target
The extracellular matrix is a richly bioactive composition of substrates that provides biophysical stability, facilitates intercellular signaling,...
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Marine Collagen for Delivery of Therapeutics
Collagen is the most plentiful protein in mammals and considered the most significant part of the body structurally and functionally. The marine...
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Plasmodium vivax tryptophan-rich antigen reduces type I collagen secretion via the NF-κBp65 pathway in splenic fibroblasts
BackgroundThe spleen plays a critical role in the immune response against malaria parasite infection, where splenic fibroblasts (SFs) are abundantly...
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HNRNPC promotes collagen fiber alignment and immune evasion in breast cancer via activation of the VIRMA-mediated TFAP2A/DDR1 axis
BackgroundCancers aggressively reorganize collagen in their microenvironment, leading to the evasion of tumor cells from immune surveillance....
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Natural compound fraxinellone ameliorates intestinal fibrosis in mice via direct intervention of HSP47-collagen interaction in the epithelium
Intestinal fibrosis is a common complication of inflammatory bowel disease. There is still a lack of effective drugs for the prevention or treatment...
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Collagen type I-mediated mechanotransduction controls epithelial cell fate conversion during intestinal inflammation
BackgroundThe emerging concepts of fetal-like reprogramming following tissue injury have been well recognized as an important cue for resolving...
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Senescent fibroblast facilitates re-epithelization and collagen deposition in radiation-induced skin injury through IL-33-mediated macrophage polarization
BackgroundThe need for radiotherapy among the elderly rises with increasing life expectancy and a corresponding increase of elderly cancer patients....
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Biseugenol from Ocotea cymbarum (Lauraceae) attenuates inflammation, angiogenesis and collagen deposition of sponge-induced fibrovascular tissue in mice
Several species of the genus Ocotea are used in traditional medicine due to their anti-inflammatory and analgesic properties. In this work we sought...
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Type I collagen and fibromodulin enhance the tenogenic phenotype of hASCs and their potential for tendon regeneration
Our previous work demonstrated the tendon-derived extracellular matrix (ECM) extracts as vital niches to specifically direct mesenchymal stem cells...
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Neoadjuvant therapy alters the collagen architecture of pancreatic cancer tissue via Ephrin-A5
BackgroundThe treatment of pancreatic cancer (PDAC) remains clinically challenging, and neoadjuvant therapy (NAT) offers down staging and improved...
